Stimulation of human gamma delta T cells by nonpeptidic mycobacterial ligands.
basic_science · Level V
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Abstract
Most human peripheral blood gamma delta T lymphocytes respond to hitherto unidentified mycobacterial antigens. Four ligands from Mycobacterium tuberculosis strain H37Rv that stimulated proliferation of a major human gamma delta T cell subset were isolated and partially characterized. One of these ligands, TUBag4, is a 5' triphosphorylated thymidine-containing compound, to which the three other stimulatory molecules are structurally related. These findings support the hypothesis that some gamma delta T cells recognize nonpeptidic ligands.
Medical subject headings
- Antigens, Bacterial
- Lymphocyte Activation
- Mycobacterium tuberculosis
- Receptors, Antigen, T-Cell, gamma-delta
- T-Lymphocyte Subsets
- Thymine Nucleotides