Secondary solid malignant tumors occurring after bone marrow transplantation for severe aplastic anemia given thoraco-abdominal irradiation.
case_series · Level IV
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Abstract
We have evaluated irradiation doses received at location of secondary solid tumors occurring after bone marrow transplantation (BMT) in five of 147 patients grafted for severe aplastic anaemia. All 5 tumors occurred within the radiation field penumbra. The estimated received dose varied from 6 Gy for one inner field secondary tumor, to 2.5 Gy for the remaining secondary tumors. Tumors may arise in the zone where the delivered radiation dose drops dramatically. Irradiation, with associated cofactors, may promote the development of epidermoid carcinoma in irradiated patients for BMT.
Medical subject headings
- Anemia, Aplastic
- Bone Marrow Transplantation
- Carcinoma, Mucoepidermoid
- Carcinoma, Squamous Cell
- Head and Neck Neoplasms
- Lymphatic Irradiation
- Neoplasms, Radiation-Induced