Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 8160017.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Transgenic mice were created with cardiac-specific overexpression of the beta 2-adrenergic receptor. This resulted in increased basal myocardial adenylyl cyclase activity, enhanced atrial contractility, and increased left ventricular function in vivo; these parameters at baseline in the transgenic animals were equal to those observed in control animals maximally stimulated with isoproterenol. These results illustrate a useful approach for studying the effect of gene expression on cardiac contractility. Because chronic heart failure in humans is accompanied by a reduction in the number of myocardial beta-adrenergic receptors and in inotropic responsiveness, these results suggest a potential gene therapy approach to this disease state.
Medical subject headings
- Adenylyl Cyclases
- Myocardial Contraction
- Myocardium
- Receptors, Adrenergic, beta
- Ventricular Function, Left