Monocyte activity in the presence of calcium phosphate activated by 1,25 (OH)2 VD3 and interferon-gamma.
basic_science · Level V
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Abstract
The monocyte is an essential element in cellular immunity. Consequently, its role in the biocompatibility process is important. A model study of the degradation of bioactive ceramics (calcium phosphate) using human peripheral blood monocytes activated by 1,25 (OH)2 VD3 and interferon (IFN)-gamma was implemented. Activated monocytes cultivated on calcium phosphate tablets led to cellular morphological modifications and to changes in the number of nuclei (from d 2 to 14). IFN-gamma promoted adhesion, the appearance of cytoplasmic extensions and multinuclei. Cavity resorption activity on the material was observed simultaneously.
Medical subject headings
- Calcitriol
- Calcium Phosphates
- Ceramics
- Interferon-gamma
- Monocytes