Familial clustering of multiple sclerosis in a northern Swedish rural district.
case_series · Level IV
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- Record sourced from PubMed, PMID 8164003.
- Also identified by PMC identifier 1072883.
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Abstract
A small rural district in the most northerly province of Sweden was found to have a very high occurrence of multiple sclerosis. A total of 12 patients with multiple sclerosis among 4744 inhabitants were identified (five females, seven males), corresponding to a prevalence of 253/100,000. Many of the patients were related and a further 21 cases with multiple sclerosis (14 females, seven males), mostly living in the neighbouring area, have family ties to the district. A genealogical investigation showed that 22 of the 33 patients identified had ties of kinship and thus, to our knowledge, the largest aggregation of multiple sclerosis in a family is presented.
Medical subject headings
- Multiple Sclerosis