3 cases of anti-Scl-70 (topoisomerase I) antibody associated with central nervous system lupus without renal disorder.
case_report · Level V
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Abstract
We describe 3 cases of systemic lupus erythematosus (SLE) associated with anti-Scl-70 antibody. Common symptoms were central nervous system disorder, discoid rash, lymphadenopathy, and no renal disorder. Two of 3 cases showed some symptoms of scleroderma but could not be diagnosed as such. Although further followup is required to determine if scleroderma develops, these unique symptoms might be a subtype of SLE or a lupus-like syndrome characterized by symptoms and anti-Scl-70 antibody.
Medical subject headings
- Antibodies
- Central Nervous System Diseases
- DNA Topoisomerases, Type I
- Lupus Erythematosus, Systemic