Optimal drug and behavior therapy for treatment-refractory schizophrenic patients.

Liberman, R P; Van Putten, T; Marshall, B D; Mintz, J; Bowen, L; Kuehnel, T G; Aravagiri, M; Marder, S R · Am J Psychiatry · 1994

case_series · Level IV

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Abstract

Thirteen treatment-refractory schizophrenic patients (10 men and three women) who were receiving more than 50 mg/day of haloperidol and who had been hospitalized for more than 1 year successfully tolerated a mean dose reduction of 63% with consequent improvement in psychopathology and side effects. The addition of intensive behavior therapy to the optimal dose of haloperidol yielded further improvements in functional behavior, such as self-care and social interaction.

Medical subject headings