Oncology and hematology.

Karp, J E; Broder, S · JAMA · 1994

review · Level V

Where this comes from

Abstract

Net overexpression or derangements of PTK-encoding oncogenes and ras serve as critical driving forces in the evolution of many epithelial and lymphohematopoietic cancers. The ability to impede signal transduction through ras-based pathways could provide a powerful molecular target for therapy and prevention of a broad spectrum of malignant neoplasms.

Medical subject headings