An inflammatory eruption associated with recombinant human IL-6.

Fleming, T E; Mirando, W S; Soohoo, L F; Cooper, B W; Zaim, M T; Lazarus, H M; Elmets, C A · Br J Dermatol · 1994

case_report · Level V

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Abstract

Interleukin 6 (IL-6) is an endogenous cytokine with multiple biological functions, including amplification of the inflammatory response. Recombinant human IL-6, administered as part of a chemotherapeutic regimen, has recently been shown to cause regression of certain types of malignant tumours. We report a patient who developed a cutaneous eruption consisting of coalescent, erythematous, scaling macules and papules after administration of recombinant human IL-6, given as part of her chemotherapy for ductal carcinoma of the breast.

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