An algorithm to generate low-resolution protein tertiary structures from knowledge of secondary structure.
basic_science · Level V
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- Record sourced from PubMed, PMID 8197177.
- Also identified by PMC identifier 43923.
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Abstract
An algorithm is described to assemble the three-dimensional fold of a protein starting from its secondary structure. A reduced representation of the polypeptide chain is used together with a crude potential based on pair hydrophobicities. The method is shown to be successful in locating the native topology for two 4-alpha-helix bundles, myohemerythrin and cytochrome b-562.
Medical subject headings
- Algorithms
- Escherichia coli Proteins
- Protein Structure, Secondary
- Protein Structure, Tertiary