Positivity of patch tests in cutaneous reaction to diclofenac. Two case reports.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 8198241.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Immune-mediated reactions to NSAIDs are unusual. We have observed two cases of maculopapular eruptions occurring 48-72 h after administration of diclofenac sodium. Patch tests performed with diclofenac were positive. The histopathologic findings resembled those of contact dermatitis with different degrees of dermal involvement. Clinical, allergologic, and histopathologic patterns strongly suggest a type IV mechanism of hypersensitivity. Patch tests play an important role in the assessment of possible immunologic mechanisms underlying cutaneous reactions to drugs.
Medical subject headings
- Dermatitis, Allergic Contact
- Diclofenac
- Drug Eruptions
- Hypersensitivity, Delayed
- Parapsoriasis