Lack of efficacy of single-dose prednisolone in moderately severe asthma.
rct · Level II
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Abstract
OBJECTIVE: To assess the effectiveness of single-dose prednisolone in reducing the length of illness and hospital stay in children admitted with moderately severe asthma. DESIGN: A randomised, double-blind, controlled trial of a single dose of prednisolone in 64 children presenting with an acute attack of asthma with arterial oxygen saturation less than 93%. RESULTS: No significant differences in the rate of recovery of oxygen saturation, lung function measurements or duration of hospital stay were found. CONCLUSIONS: This study failed to confirm the benefit of a single dose of prednisolone in the management of children with acute severe asthma.
Medical subject headings
- Asthma
- Prednisolone