A cell cycle-regulated inhibitor of cyclin-dependent kinases.
basic_science · Level V
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- Record sourced from PubMed, PMID 8202483.
- Also identified by PMC identifier 43980.
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Abstract
Cyclin-dependent kinases (Cdks) previously have been shown to drive the major cell cycle transitions in eukaryotic organisms ranging from yeast to humans. We report here the identification of a 28-kDa protein, p28Ick (inhibitor of cyclin-dependent kinase), that binds to and inhibits the kinase activity of preformed Cdk/cyclin complexes from human cells. p28 inhibitory activity fluctuates during the cell cycle with maximal levels in G1 and accumulates in G1- and G0-arrested cells. These results suggest that control of the G1/S transition may be influenced by a family of Cdk inhibitors that include p28Ick and the recently described inhibitors p21Cip1/Waf1/Cap20 and p16Ink4.
Medical subject headings
- CDC2-CDC28 Kinases
- Cell Cycle
- Cyclin-Dependent Kinases
- Protein Kinase Inhibitors
- Protein Serine-Threonine Kinases