Anergic T cells as suppressor cells in vitro.
basic_science · Level V
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- Record sourced from PubMed, PMID 8202711.
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Abstract
T cell-mediated suppression is an established phenomenon, but its underlying mechanisms are obscure. An in vitro system was used to test the possibility that anergic T cells can act as specific suppressor cells. Anergic human T cells caused inhibition of antigen-specific and allospecific T cell proliferation. In order for the inhibition to occur, the anergic T cells had to be specific for the same antigen-presenting cells (APCs) as the T cells that were suppressed. The mechanism of this suppression appears to be competition for the APC surface and for locally produced interleukin-2.
Medical subject headings
- Clonal Anergy
- T-Lymphocytes, Helper-Inducer
- T-Lymphocytes, Regulatory