Repeated doses of suxamethonium in the myasthenic patient.
case_report · Level V
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Abstract
The neuromuscular block of successive doses of suxamethonium 100 mg, monitored by electromyography, was investigated in a myasthenic patient (class IIB), undergoing thymectomy. The results suggest that successive doses of suxamethonium in the myasthenic patient are followed by a progressive prolongation of the neuromuscular block. This may be attributed to rapid desensitisation of the myasthenic endplate receptors and the rapid development of phase II block, as evidence by a progressive decrease of the T4/T1 ratio.
Medical subject headings
- Myasthenia Gravis
- Neuromuscular Junction
- Succinylcholine