Systematic HRAS amplification in ovary-independent mammary tumors: correlation with progressively anaplastic phenotypes.
basic_science · Level V
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Abstract
Progression of well differentiated rat mammary adenocarcinomas to very anaplastic phenotypes was found to correlate with a systematic and significant amplification of a mutant HRAS allele. Tumors with high amplification levels of this oncogene were analyzed by chromosomal in situ hybridization; in four of the cases the amplified sequences did not reside at the native chromosome 1 locus but were localized in a novel marker chromosome. The model described has potential as a reproducible system for the study of the chromosomal and cellular mechanisms operative "in vivo" for oncogene amplification.
Medical subject headings
- Adenocarcinoma
- Alleles
- Carcinoma
- Gene Amplification
- Genes, ras
- Mammary Neoplasms, Experimental