AT III in septicemia with DIC.
review · Level V
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Abstract
In the development of sepsis DIC is a common complication. Several studies presented in this paper show a coincidence between the development of DIC and depletion of Antithrombin III, a serine protease inhibitor which inhibits a large scale of activated clotting factors. It seems very probable that substitution therapy should be of benefit in the treatment of sepsis-related DIC and may improve the outcome of septic patients. Physiological and clinical findings are put together to clarify the basic rationale for running clinical trials and future studies.
Medical subject headings
- Antithrombin III
- Antithrombin III Deficiency
- Disseminated Intravascular Coagulation
- Sepsis