Response to Haemophilus influenzae type b conjugate vaccine in chronically ill premature infants.

Washburn, L K; O'Shea, T M; Gillis, D C; Block, S M; Abramson, J S · J Pediatr · 1993

case_series · Level IV

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Abstract

Twenty-two premature infants with chronic lung disease (median gestational age 28 weeks) received polyribosylribitol phosphate-outer membrane protein conjugate Haemophilus vaccine at 2 and 4 months of chronologic age. The proportions with antibodies to polyribosylribitol phosphate at levels > 1 microgram/ml after doses 1 and 2 were 27% and 55%; geometric mean titers were 0.43 and 0.73 microgram/ml, significantly lower than values for term infants.

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