Are pill counts valid measures of compliance in clinical obstetric trials?

DuBard, M B; Goldenberg, R L; Copper, R L; Hauth, J C · Am J Obstet Gynecol · 1993

rct · Level II

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Abstract

We compared pill counts with a biochemical measure of compliance in 283 women who participated in a randomized double-blind trial that evaluated the efficacy of low-dose aspirin in the prevention of preeclampsia. Subjects whose pill counts indicated a usage > 100% were less compliant than women with lower pill counts.

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