The influence of antigen organization on B cell responsiveness.
basic_science · Level V
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- Record sourced from PubMed, PMID 8248784.
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Abstract
The influence of antigen epitope density and order on B cell induction and antibody production was assessed with the glycoprotein of vesicular stomatitis virus serotype Indiana [VSV-G (IND)]. VSV-G (IND) can be found in a highly repetitive form the envelope of VSV-IND and in a poorly organized form on the surface of infected cells. In VSV-G (IND) transgenic mice, B cells were unresponsive to the poorly organized VSV-G (IND) present as self antigen but responded promptly to the same antigen presented in the highly organized form. Thus, antigen organization influences B cell tolerance.
Medical subject headings
- Antibodies, Viral
- B-Lymphocytes
- Immune Tolerance
- Membrane Glycoproteins
- Vesicular stomatitis Indiana virus
- Viral Envelope Proteins