Peripheral antinociceptive effects of morphine after burn injury.
rct · Level II
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- Record sourced from PubMed, PMID 8249563.
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Abstract
In a double-blind study, 2 mg of morphine in saline, or saline only, was given subcutaneously into a second-degree bilateral leg-burn injury in 12 volunteers. Heat-pain thresholds and pressure-pain thresholds were significantly increased by local morphine administration. These results confirm experimental data demonstrating a peripheral antinociceptive effects of opioids in inflamed tissue.
Medical subject headings
- Burns
- Morphine
- Pain
- Pain Threshold