Partial regression of Barrett's esophagus--an inadequate endpoint.
case_report · Level V
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- Record sourced from PubMed, PMID 8249978.
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Abstract
A patient with Barrett's esophagus and high grade dysplasia is presented. He underwent a fundoplication and, subsequently, nearly three years of high-dose proton pump inhibition therapy. At the time of esophagogastrectomy, extensive squamous re-epithelialization was observed along with two histologic foci of intramucosal adenocarcinoma. Despite partial regression of Barrett's esophagus, high grade dysplasia present for more than 4 years had progressed to adenocarcinoma. Partial squamous repopulation of Barrett's esophagus is an inadequate endpoint of therapy. Complete regression is necessary to eliminate the risk of cancer.
Medical subject headings
- Barrett Esophagus