Multiple hamartoma syndrome with osteosarcoma.
case_report · Level V
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- Record sourced from PubMed, PMID 8250698.
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Abstract
Multiple hamartoma syndrome, also known as Cowden's disease, is a rare genodermatosis with characteristic mucocutaneous lesions associated with multiple internal abnormalities. We describe a patient having classic dermatologic manifestations of Cowden's disease and multiple neoplasia including follicular adenocarcinoma of the thyroid gland with lung metastasis, intraductal breast carcinoma within a fibroadenoma, and an osteosarcoma. To our knowledge, this is the first reported case of an osteosarcoma in Cowden's disease.
Medical subject headings
- Bone Neoplasms
- Hamartoma Syndrome, Multiple
- Osteosarcoma
- Thyroid Neoplasms