Fanconi's anaemia associated with multicentric Bowen's disease and decreased NK cytotoxicity.
case_report · Level V
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Abstract
We report a patient with Fanconi's anaemia and multiple lesions of vulvo-anal Bowen's disease. She was thrombocytopenic and lymphopenic, and NK-mediated cytotoxicity was undetectable. The vulvar lesions did not contain papillomavirus DNA. In vitro studies showed a possible benefit from acitretin treatment on bone marrow stem cells. However, low-dose acitretin given for 14 months did not prevent the development of an anal squamous carcinoma. Acitretin therapy was, however, associated with a sustained rise in the platelet count.
Medical subject headings
- Bowen's Disease
- Cytotoxicity, Immunologic
- Fanconi Anemia
- Killer Cells, Natural
- Skin Neoplasms