Effects of octreotide on circulating islet B cell products in endogenous hyperinsulinism.
case_report · Level V
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- Record sourced from PubMed, PMID 8255845.
- Also identified by PMC identifier 2399757.
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Abstract
The role of somatostatin analogues in the medical management of insulinomas is unclear. We describe an elderly patient with clinical and biochemical features of endogenous hyperinsulinism attributable to a benign islet B cell disorder whose incapacitating neuroglycopaenic symptoms responded dramatically to octreotide 50 micrograms subcutaneously at 2200 h each night. Octreotide suppressed inappropriate plasma concentrations of insulin thereby preventing fasting hypoglycaemia. Fasting concentrations of proinsulin, and 32-33 split proinsulin, as determined by two-site monoclonal antibody-based immunoradiometric assays, were also suppressed by octreotide.
Medical subject headings
- Hyperinsulinism
- Insulinoma
- Octreotide
- Pancreatic Neoplasms