The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 8259210.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft between a domain structurally homologous to small GTPases and a helical domain unique to heterotrimeric G proteins. The structure, when combined with biochemical and genetic studies, suggests: how an activated receptor might open this cleft to allow nucleotide exchange; a mechanism for GTP-induced changes in effector and receptor binding surfaces; and a mechanism for GTPase activity not evident from previous data.
Medical subject headings
- Guanosine 5'-O-(3-Thiotriphosphate)
- Transducin