Sevoflurane does not increase intracranial pressure in hyperventilated dogs.
Level III
Where this comes from
- Record sourced from PubMed, PMID 8260306.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We have measured the effects of 0.5, 1.0 and 1.5 MAC (minimum alveolar concentration) end-tidal concentrations of sevoflurane on intracranial pressure (ICP), cerebral perfusion pressure (CPP), mean arterial pressure (MAP), central venous pressure and heart rate in hypocapnic dogs (PaCO2 3.2-3.7 kPa) and compared the data with those produced by equi-MAC concentrations of enflurane and halothane. Enflurane and halothane caused small but significant increases in ICP at 0.5, 1.0 and 1.5 MAC, but there were no changes with sevoflurane. However, sevoflurane caused a considerable decrease in MAP with consequent decrease in CPP. We conclude that sevoflurane should be a suitable agent for neuroanaesthesia and is preferable to either enflurane or halothane.
Medical subject headings
- Anesthetics
- Ethers
- Intracranial Pressure
- Methyl Ethers