Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 8266081.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Yin-Yang-1 (YY1) regulates the transcription of many genes, including the oncogenes c-fos and c-myc. Depending on the context, YY1 acts as a transcriptional repressor, a transcriptional activator, or a transcriptional initiator. The yeast two-hybrid system was used to screen a human complementary DNA (cDNA) library for proteins that associate with YY1, and a c-myc cDNA was isolated. Affinity chromatography confirmed that YY1 associates with c-Myc but not with Max. In cotransfections, c-Myc inhibits both the repressor and the activator functions of YY1, which suggests that one way c-Myc acts is by modulating the activity of YY1.
Medical subject headings
- DNA-Binding Proteins
- Proto-Oncogene Proteins c-myc
- Transcription Factors
- Zinc Fingers