A double-blind, placebo-controlled crossover study of ganglioside GM1 treatment for Alzheimer's disease.
rct · Level II
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Abstract
In a double-blind trial, 12 patients with probable Alzheimer's disease were treated for 6 weeks with placebo and 6 weeks with monosialoganglioside (GM1) (100 mg/day i.m.), which potentiates the actions of nerve growth factor. GM1 failed to produce significant improvement in patients' cognitive test performance, suggesting that this is not a viable approach to the treatment of cognitive deterioration in Alzheimer's disease.
Medical subject headings
- Alzheimer Disease
- Gangliosides