Cardiac synovial sarcoma with translocation (X;18) associated with asbestos exposure.
case_report · Level V
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- Record sourced from PubMed, PMID 8275440.
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Abstract
A primary cardiac spindle cell tumor with immunoreactivity for keratin proteins is reported. Cytogenetic analysis of the tumor demonstrated a translocation (X;18), an aberration almost exclusively reported in synovial sarcomas. Postmortem examination revealed amphibole asbestos within the lungs and diaphragmatic pleural plaques indicative of asbestos exposure. These findings raise questions about the possible causation of this tumor.
Medical subject headings
- Asbestos, Amosite
- Chromosomes, Human, Pair 18
- Heart Neoplasms
- Occupational Exposure
- Sarcoma, Synovial
- Translocation, Genetic
- X Chromosome