Genetic susceptibility to fixed drug eruption: evidence for a link with HLA-B22.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 8277031.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Our observation of familial cases of fixed drug eruption (FDE) prompted us to consider a genetic predisposition to this disease. Our purpose was to determine whether there is any association between FDE and any of the major histocompatibility complex class I or II alleles. HLA class I and II typing was performed by lymphocytotoxicity assay in 36 unrelated patients with FDE. Significantly higher (p < 0.0001) frequencies of the B22 and Cw1 antigens were found in the 36 patients with FDE. Our data are the first to suggest a genetic predisposition to FDE.
Medical subject headings
- Drug Eruptions
- HLA-B Antigens