Myoclonic spasms during treatment with high doses of intravenous morphine in renal failure.
case_report · Level V
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Abstract
Myoclonic spasms occurred in a patient suffering from renal failure after high doses of continuous intravenous morphine (100 mg/h). The concentrations of morphine, morphine-6-glucuronide and morphine-3-glucuronide (mumol/l) in plasma were: 1.93, 52.06 and 381.8, and in cerebrospinal fluid were: 1.02, 5.86 and 61.82, respectively. The role of morphine and morphine glucuronides in myoclonic spasms is discussed.
Medical subject headings
- Acute Kidney Injury
- Epilepsies, Myoclonic
- Morphine
- Renal Dialysis