Left ventricular hypertrophy in asymptomatic essential hypertension: its relationship with aldosterone and the increase in sodium-proton exchanger activity.

Abstract

In order to analyse the hormonal and erythrocyte ion transport systems in relation to left ventricular hypertrophy (LV) in essential hypertension, a prospective study of 50 consecutive hypertensive patients under 55 years of age and without prior antihypertensive therapy was performed. Twenty-seven normal subjects with no family history of hypertension served as controls. LV hypertrophy, as assessed by echocardiography, was present in 64% of the hypertensive patients. This showed an increase (P < 0.001) in intra-erythrocyte Na+ concentration (8.1 +/- 1.2 vs 6.9 +/- 1 mmol.l-1.cells-1) and Na+:H+ exchange activity (8.8 +/- 4 vs 5.5 +/- 1.3 mmol.[l.cells.h-1]). There was a significant association between plasma aldosterone levels (19.1 +/- 12 ng.dl-1) with intra-erythrocyte Na+ content (r = 0.370, P < 0.05) and Na+:H+ exchange activity (r = 0.385, P < 0.01) as well as with echocardiographic LV mass index (138 +/- 40 g.m-2, r = 0.393, P < 0.01). The results are consistent with the concept that increased entry of Na+ into cells via Na+:H+ exchange could be a determining factor in left ventricular hypertrophy, which might be influenced by aldosterone.