A case of central diabetes insipidus with spontaneous remission after 8 years of the disease.

Nagae, A; Kohara, K; Iwata, T; Okura, T; Ohtsuka, T; Kukita, H; Hiwada, K · J Intern Med · 1994

case_report · Level V

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Abstract

A 55-year-old male smoker developed polyuria and polydipsia in November 1983. A water deprivation study revealed a defect in the urine concentrating function, which was corrected by vasopressin. Plasma antidiuretic hormone (ADH) was not increased by smoking. His condition was well controlled by deamino-D-arginine vasopressin. However, since February 1992 he has become completely free from the need for medication to control his urine volume. Re-evaluation studies with water deprivation and smoking revealed dramatic improvements in the urine concentrating function and ADH response. A patient with idiopathic diabetes insipidus with spontaneous remission after 8 years is reported.

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