Sumatriptan blocks neurogenic inflammation in the peripheral nerve trunk.
basic_science · Level V
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Abstract
We tested the action of intraperitoneal sumatriptan, a 5-HT1D receptor agonist that aborts migraine headaches, using a model of neurogenic inflammation induced by capsaicin applied to the rat sciatic epineurium. Sumatriptan prevented the development of capsaicin-induced hyperemia without inducing pretreatment vasoconstriction or altering AV shunt flow. The findings indicate that sumatriptan prevents "neurogenic" vasodilation by a mechanism other than vasoconstriction or changes in AV shunt flow.
Medical subject headings
- Neuritis
- Sciatic Nerve
- Sumatriptan