Type IV renal tubular acidosis and spironolactone therapy in the elderly.

O'Connell, J E; Colledge, N R · Postgrad Med J · 1993

case_report · Level V

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Abstract

Spironolactone therapy is a well-known cause of hyperkalaemia, but in susceptible patient, it may also be associated with metabolic acidosis. We report a case of severe renal tubular acidosis (Type IV) with life-threatening hyperkalaemia caused by spironolactone, and discuss the mechanisms by which this may occur.

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