Function of a human cyclin gene as an oncogene.
basic_science · Level V
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- Record sourced from PubMed, PMID 8290586.
- Also identified by PMC identifier 43018.
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Abstract
The cyclin D1 (PRAD1, CCND1) gene is affected by translocations and amplification in the genomes of a number of human tumors, suggesting that these changes confer growth advantage on developing tumor cell clones. We show here that in cultured cells, a cDNA clone of the cyclin D1 gene can contribute to cell transformation by complementing a defective adenovirus E1A oncogene. In such cells, this candidate oncogene indeed functions like an oncogene, suggesting a similar role in tumor progression in vivo.
Medical subject headings
- Cyclins
- Oncogene Proteins
- Oncogenes