Refined genetic mapping of X-linked Charcot-Marie-Tooth neuropathy.
basic_science · Level V
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- Record sourced from PubMed, PMID 8304339.
- Also identified by PMC identifier 1918155.
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Abstract
Genetic linkage studies were conducted in four multigenerational families with X-linked Charcot-Marie-Tooth disease (CMTX), using 12 highly polymorphic short-tandem-repeat markers for the pericentromeric region of the X chromosome. Pairwise linkage analysis with individual markers confirmed tight linkage of CMTX to the pericentromeric region in each family. Multipoint analyses strongly support the order DXS337-CMTX-DXS441-(DXS56,PGK1).
Medical subject headings
- Charcot-Marie-Tooth Disease
- Genetic Linkage
- X Chromosome