Measurement of acetylcholine receptor function in microcircuit-coupled myoblasts.
basic_science · Level V
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Abstract
An electrophysiological measurement principle for long-term, noninvasive monitoring of the nicotinic acetylcholine receptor (nAChR) function is described. The measurement is based on the ability to record agonist-induced depolarizations of clonal myoblasts that have formed high impedance seals with extracellular microcircuit electrodes. The technique appears promising for several types of assays and environmental monitoring applications.
Medical subject headings
- Electrophysiology
- Receptors, Cholinergic