Dose-volume effects in the spinal cord.

van der Kogel, A J · Radiother Oncol · 1993

basic_science · Level V

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Abstract

Experimental data on dose-volume relationships for the spinal cord are now available for a variety of animal models (monkey, dog, pig, rat). Most studies show a marginal volume effect for cord lengths longer than 1 cm, but a steep increase in tolerance doses for irradiated lengths of less than 1 cm. From a comparison of several theoretical models with available clinical/experimental data it can be concluded that there is at present no need for a further expansion of models, but a great need of reliable data.

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