Clinical and histological evaluation of interferon alfa-2b in the treatment of chronic hepatitis C.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 8314478.
- Also identified by PMC identifier 1374036.
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Abstract
In a study of 37 patients with hepatitis C (proved histologically) positive chronic hepatitis, a correlation was seen between clinical efficacy and histological improvement after treatment with interferon alfa-2b (3 million units (MU) three times a week for six months plus six months' follow up). Alanine aminotransferase activities became normal in 18 (48%) patients during treatment; at the end of follow up eight (45%) had a continued response to the treatment. Paired liver biopsy specimens showed marked improvements in Knodell index score and portal inflammation in these patients.
Medical subject headings
- Hepatitis C
- Interferon-alpha