Severe phenytoin-induced bone marrow depression and agranulocytosis treated with human recombinant granulocyte-macrophage colony-stimulating factor. Case report.
case_report · Level V
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Abstract
An unusual instance of severe and potentially lethal depression of the bone marrow is described as a result of the administration of phenytoin for seizure prophylaxis. The patient was treated successfully by prompt cessation of phenytoin and intravenous administration of human recombinant granulocyte-macrophage colony-stimulating factor.
Medical subject headings
- Agranulocytosis
- Bone Marrow
- Granulocyte-Macrophage Colony-Stimulating Factor
- Phenytoin