Structure of the actin-myosin complex and its implications for muscle contraction.
basic_science · Level V
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Abstract
Muscle contraction consists of a cyclical interaction between myosin and actin driven by the concomitant hydrolysis of adenosine triphosphate (ATP). A model for the rigor complex of F actin and the myosin head was obtained by combining the molecular structures of the individual proteins with the low-resolution electron density maps of the complex derived by cryo-electron microscopy and image analysis. The spatial relation between the ATP binding pocket on myosin and the major contact area on actin suggests a working hypothesis for the crossbridge cycle that is consistent with previous independent structural and biochemical studies.
Medical subject headings
- Actins
- Actomyosin
- Models, Molecular
- Muscle Contraction
- Myosin Subfragments
- Protein Conformation