Residual Ph- cells in chronic myeloid leukemia: detection and usefulness.
basic_science · Level V
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Abstract
Bone marrow cells from patients with chronic myeloid leukemia (CML) in in vitro long-term bone marrow culture (LTBMC) show an impaired survival of Philadelphia (Ph) positive cells and, in a proportion of patients, the emergence of Philadelphia negative hemopoiesis. The standard conditions of in vitro cultures provide optimal purging effect. Selected patients can now have autologous bone marrow transplants (ABMT) with in vitro purged cells.
Medical subject headings
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Philadelphia Chromosome