Evaluation of secondary prophylactic schemes, based on benzathine penicillin G, for rheumatic fever in children.
retrospective_cohort · Level III
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Abstract
Serum concentrations of penicillin were measured in children with rheumatic fever. The adequacy of the values after administration of 1.2 million units of benzathine penicillin G every 2 or 3 weeks was confirmed; the adequacy of a 4-week regimen was questionable. The administration of 0.6 million units every 3 weeks was found to be inadequate to maintain serum levels high enough for the secondary prophylaxis of rheumatic fever.
Medical subject headings
- Penicillin G Benzathine
- Rheumatic Fever