Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast.
basic_science · Level V
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Abstract
A novel genetic selection in yeast has been used to isolate a complementary DNA for the transcriptional activator, Olf-1, which binds to the regulatory sequences of several olfactory-specific genes. The Olf-1 protein, expressed exclusively in the olfactory receptor neurons and their precursors, contains a new helix-loop-helix motif and functions as an apparent homodimer. Olf-1 may be the first member of a family of related proteins that may direct cellular differentiation in a variety of neuronal tissues.
Medical subject headings
- DNA-Binding Proteins
- Nerve Tissue Proteins
- Neurons, Afferent
- Olfactory Pathways
- Trans-Activators
- Transcription Factors