Characterization of supernumerary ring marker chromosomes by fluorescence in situ hybridization (FISH).
case_report · Level V
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- Record sourced from PubMed, PMID 8328459.
- Also identified by PMC identifier 1682354.
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Abstract
Five cases with small supernumerary ring chromosomes are characterized at the molecular level. Routine chromosome banding analysis was insufficient for identification of the ring chromosomes, and none of them was DA/DAPI positive. Fluorescence in situ hybridization utilizing repetitive centromeric probes for all chromosomes has determined that one of these five ring chromosomes originates in each of chromosomes 4, 7, 8, 9, and 20. Chromosome painting with chromosome-specific libraries has confirmed this and excluded the involvement of additional chromosomes in the rearrangements.
Medical subject headings
- Abnormalities, Multiple
- Chromosome Aberrations
- Genetic Markers
- Ring Chromosomes