Transepidermal water loss and absorption of hydrocortisone in widespread dermatitis.
case_series · Level IV
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- Record sourced from PubMed, PMID 8338747.
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Abstract
Percutaneous absorption of hydrocortisone was measured in three children and six adults with widespread dermatitis, after the application of 1% hydrocortisone cream. Before application of the cream, the transepidermal water loss (TEWL) was measured on six skin areas. A highly significant correlation was found between the post-application rise in plasma cortisol level and the mean transepidermal water loss. Thus, measurement of TEWL affords a simple, non-invasive method for assessing the systemic effect of hydrocortisone applied to widespread dermatitis.
Medical subject headings
- Dermatitis
- Hydrocortisone
- Skin
- Skin Absorption
- Water Loss, Insensible