Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae.
basic_science · Level V
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- Record sourced from PubMed, PMID 8341678.
- Also identified by PMC identifier 46984.
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Abstract
The full activity of a recombination initiation site located 5' of HIS4 requires the binding of the transcription factors RAP1, BAS1, and BAS2. Two RAP1 binding sites can substitute for the wild-type initiation site. A 51-bp region of telomeric DNA inserted upstream of either HIS4 or ARG4 very strongly stimulates recombination. We suggest that the ability of transcription factors to induce recombination is a consequence of an altered chromatin structure that favors the entry of proteins that initiate recombination, rather than an effect of these factors on transcription.
Medical subject headings
- Genes, Fungal
- Homeodomain Proteins
- Recombination, Genetic
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Transcription Factors