Malignant osteopetrosis treated with high doses of 1 alpha-hydroxyvitamin D3 and interferon gamma.
case_report · Level V
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- Record sourced from PubMed, PMID 8345424.
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Abstract
A male infant with malignant osteopetrosis was treated with high doses of 1 alpha-hydroxyvitamin D3 and interferon gamma. Therapy with 1 alpha-hydroxyvitamin D3 increased the serum calcium level despite the markedly elevated serum level of 1 alpha, 25-dihydroxyvitamin D before treatment. Recombinant human interferon gamma increased neither the bone mineral nor matrix turnover, and was not tolerated because of bone marrow suppression.
Medical subject headings
- Hydroxycholecalciferols
- Interferon-gamma
- Osteopetrosis